Recombinant Human GLP-1 Receptor/GLP1R Protein (C-hFc)

Measured by functional ELISA. Immobilized recombinant human GLP-1R ECD binds GLP-1(7-36) amide and reference GLP-1R-targeting peptides with EC50 values in the ng/mL range.

The glucagon-like peptide-1 receptor (GLP-1R) is a class B GPCR that translates incretin signaling into glucose-dependent insulin secretion, appetite suppression and cardiovascular benefit — the pharmacology behind the semaglutide, liraglutide and tirzepatide therapeutic revolution in type 2 diabetes and obesity. Its extracellular ligand-binding domain is the primary determinant of peptide-agonist recognition, capturing the C-terminal helix of GLP-1 and engineered analogs before membrane-domain activation. The dimeric hFc fusion presented here stabilizes the ECD for plate-based and label-free binding assays, supporting analog screening, affinity ranking and pharmacodynamic comparator testing across the incretin development landscape.